La paradoja del hierro

Elizabeth Brassea Pérez VANESSA LABRADA MARTAGON JOSÉ PABLO VÁZQUEZ MEDINA Ramón Gaxiola Robles CLAUDIA JANETL HERNANDEZ CAMACHO TANIA ZENTENO SAVIN (2022)

"El hierro (Fe) es un micromineral abundante en nuestro planeta, el cual participa en procesos biológicos importantes como el transporte de oxígeno en la sangre y la formación del colágeno en los tejidos. A pesar de su disponibilidad en el ambiente y en diversos alimentos, la deficiencia de hierro en el cuerpo humano es común, pudiendo generar problemas de salud. La anemia ferropénica es una condición relacionada a una deficiencia de hierro, disminución en los niveles de hemoglobina y alteraciones en la morfología de las células encargadas de transportar oxígeno en nuestra sangre, los glóbulos rojos. Esta condición ocurre en todas las edades; sin embargo, su prevalencia es mayor en niños(as) menores de 2 años. Aunque puede inducirse por diversos factores, la anemia ferropénica se presenta en mayor medida en individuos con un estado nutricional de hierro insuficiente. Otras causas pueden ser la interacción del hierro con otros nutrientes, pérdidas o excreción y por requerimientos de crecimiento. A nivel mundial, es considerada un problema de salud pública, ya que conlleva a importantes implicaciones sobre la salud humana. Por lo que mantener los niveles adecuados de hierro en nuestro cuerpo a través de una dieta saludable es importante para nuestro crecimiento, salud y resistencia a enfermedades."

"Iron (Fe) is an abundant micromineral in our planet that participates in important biological processes, such as the transport of oxygen in the blood and the formation of collagen in the tissues. Despite its availability in the environment and a variety food items, iron deficiency in the human body is common and could lead to health issues. Iron-deficiency anemia is a condition related to iron deficiency, decrease in hemoglobin levels and alterations in the morphology of the cells responsable for transporting oxygen in our blood, the red blood cells. This condition occurs at all ages; however, its prevalence is higher in children under 2 years old. Although it can be induced by various factors, iron deficiency anemia occurs to a greater rate in individuals with an insufficient iron nutritional status. Other causes may be the interaction of iron with other nutrients, losses or excretion and growth requirements. Globally, it is considered a public health problem, as it has important implications on human health. Therefore, maintaining adequate levels of iron in our body through a healthy diet is important for our development, health, and resistance to diseases."

Artículo

anemia ferropénica, hierro, nutrición, salud, reacción de Fenton MEDICINA Y CIENCIAS DE LA SALUD CIENCIAS MÉDICAS CIENCIAS DE LA NUTRICIÓN VITAMINAS VITAMINAS

Morphological Alterations in Human Skeletal Muscle Cells Exposed to di-(2-Ethylhexyl) Phthalate (dehp) in Primary Cell Culture Conditions

Alteraciones Morfológicas en Células Musculares Esqueléticas Humanas Expuestas a Ftalato de di-(2-etilhexilo) (dehp) en Condiciones de Cultivo Celular Primario

Pablo Hernández Almaraz ORLANDO LUGO LUGO Ramón Gaxiola Robles OSCAR KURT BITZER QUINTERO Luis Javier Ramírez Jirano Elizabeth Brassea Pérez TANIA ZENTENO SAVIN (2022)

"Di-(2-ethylhexyl) phthalate (DEHP) is among the most common plasticizer additives that humans are in contact with daily. DEHP can be released from plastic and enter the human body, whereby it is metabolized and transformed into oxidative hydrophilic molecules. Clinical follow-ups in patients exposed to this phthalate and investigations in cultures of several cell types have provided information on its effects. For example, it is associated with inhibition of diploid human cell development and morphological changes in cultured germ cells. Although skeletal muscle represents around 50 % of the human body mass, knowledge about the effects of DEHP on this tissue is poor. Cultured skeletal muscle cells were exposed to DEHP (1 mM) for 13 days with the aim of exploring and evaluating some of the potential morphological effects. Three culture development parameters and nine cell characteristics were monitored during the bioassay. At 13 days, growth area, cell viability, and concentration of total proteins were lower in DEHP exposed than in control cells. Cell width and area, as well as the diameter of the nucleus and nucleolus, were greater in exposed cells than in control cells. These are interpreted as signs of cytotoxicity and suggest potential adverse effects on the development of skeletal muscle cells from DEHP exposure, as reported for other cell types."

Artículo

Emerging pollutants, Morphometry, Phthalates, Plasticizers, Toxicity MEDICINA Y CIENCIAS DE LA SALUD CIENCIAS MÉDICAS BIOLOGÍA HUMANA FISIOLOGÍA DEL MÚSCULO FISIOLOGÍA DEL MÚSCULO