Título
Haplotype-based genome-wide association study unveils stable genomic regions for grain yield in CIMMYT spring bread wheat
Autor
deepmala sehgal
Suchismita Mondal
Leonardo Abdiel Crespo Herrera
Govindan Velu
Philomin Juliana
JULIO HUERTA_ESPINO
Sandesh Kumar Shrestha
Jesse Poland
Ravi Singh
Susanne Dreisigacker
Nivel de Acceso
Acceso Abierto
Descripción
Abstracto - Genetic architecture of grain yield (GY) has been extensively investigated in wheat using genome wide association study (GWAS) approach. However, most studies have used small panel sizes in combination with large genotypic data, typical examples of the so-called ‘large p small n’ or ‘short-fat data’ problem. Further, use of bi-allelic SNPs accentuated ‘missing heritability’ issues and therefore reported markers had limited impact in wheat breeding. We performed haplotype-based GWAS using 519 haplotype blocks on seven large cohorts of advanced CIMMYT spring bread wheat lines comprising overall 6,333 genotypes. In addition, epistatic interactions among the genome-wide haplotypes were investigated, an important aspect which has not yet been fully explored in wheat GWAS in order to address the missing heritability. Our results unveiled the intricate genetic architecture of GY controlled by both main and epistatic effects. The importance of these results from practical applications in the CIMMYT breeding program is discussed.
Editor
International Maize and Wheat Improvement Center
Fecha de publicación
2020
Tipo de recurso
Dataset
Recurso de información
Repositorio Orígen
Repositorio Institucional de Datos y Software de Investigación del CIMMYT
Descargas
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