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Association between nonalcoholic fatty liver disease and severe male reproductive organ impairment (Germinal Epithelial Loss): Study on a mouse model and on human patients

URIEL ALEJANDRO LOPEZ LEMUS RAQUEL GARZA GUAJARDO ORALIA BARBOZA QUINTANA ALEJANDRINA RODRIGUEZ HERNANDEZ José Guzmán Esquivel ALEJANDRO GARCÍA RIVERA VIOLETA M. MADRIGAL PÉREZ LAURA ELVIRA GARCÍA LABASTIDA ALEJANDRO DAVID SORIANO HERNANDEZ MARGARITA DE LA LUZ MARTINEZ FIERRO IRAM PABLO RODRIGUEZ SANCHEZ ELIZABETH SANCHEZ DUARTE ARIANA CABRERA LICONA GABRIEL CEJA ESPIRITU IVAN DELGADO ENCISO (2018, [Artículo])

Metabolic syndrome (MS) has been associated with testicular damage. Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease that affects different organs, but its effect on the testes is unknown. A study analyzing germ cell involvement on BALB/c mice was carried out. A parallel comparative study was conducted that investigated alterations in the germinal epithelium of male humans that died from an unrelated acute event. The complete medical histories and histologic samples of the thoracic aorta, liver tissue, and testicular tissue from the deceased subjects were collected. The degree of germinal epithelial loss (DGEL) was evaluated and the clinical and histologic data were compared between individuals with and without NAFLD. The only metabolic or morphologic variable that caused a significant difference in the DGEL, in both the animal model and humans, was the presence of liver steatosis. The percentage of steatosis was also correlated with the percentage of the DGEL. In humans, steatosis (greater than 20%) increased the risk 12-fold for presenting with a severe DGEL (OR: 12.5; 95% CI [1.2, 128.9]; p = .03). There was no association with age above 50 years or MS components. Steatosis grade was also correlated with atherosclerosis grade. NAFLD was a strongly associated factor implicated in severe DGEL, as well as the testis was identified as a probable target organ for damage caused by the disease. his finding could result in the search for new approach strategies in the management of men with fertility problems. Further studies are required to confirm these results.

MEDICINA Y CIENCIAS DE LA SALUD Germ cells Atherosclerosis Testis Metabolic syndrome

Risk, Covid-19 and hospital care in Mexico City: Are we moving toward a new medical practice?

Rubén Muñoz (2023, [Artículo, Artículo])

Covid-19 pandemic has entailed new challenges for health care in the Mexican public health sector, producing changes in clinical practices that are now handling patients infected with covid-19 and also outpatient consultations at tertiary-level care hospitals. Some of these challenges are related to the perception of risk held by physicians regarding the possibility of contracting or transmitting covid-19 during their work,and to the management of risk from the standpoint of biomedical organizational culture linked to the material and symbolic conditions of public health services predating the pandemic. We analyze these issues from a anthropological research based on in-depth interviews to physicians that work with covid-19 patients at “Covid-19 hospitals” or “hybrid hospitals” in Mexico City. Covid-19 has arrived in social relations and perceptions of risk in the arena of health care and involves knowing and transforming some structural and symbolic conditions, resignified with the pandemic, for proper medical care.

Covid-19 percepción de riesgo personal de salud atención médica hospitalaria cultura organizacional biomédica CIENCIAS SOCIALES CIENCIAS SOCIALES risk perception health care workers hospital care biomedical organizational culture

Vida de un muerto. Entre nuestro universo y el otro

Nicolás Amoroso Boelcke (2023, [Capítulo de libro])

Capítulo número 3 de la Sección Imágenes y representaciones.

Se analiza el film Raymond & Ray, desde la construcción de la vida de Harris, personaje muerto desde el principio del film, y esto se hace mediante las palabras, no con escenas de la infancia que mencionan Raymond y Ray ni tampoco en las acciones que participa con los otros perso¬najes que hablan de él. Harris habita el filme desde las palabras.

Semiotics and motion pictures. Culture--Semiotic models. Dialogue analysis. Semiótica y cine. Análisis del diálogo. NX180.S46 HUMANIDADES Y CIENCIAS DE LA CONDUCTA CIENCIAS DE LAS ARTES Y LAS LETRAS TEORÍA, ANÁLISIS Y CRÍTICA DE LAS BELLAS ARTES CINEMATOGRAFÍA

Hacia el desarrollo de un nuevo antiparasitario basado en células en suspensión de Carica papaya

CYNTHIA ALEJANDRA GUZMÁN MEDINA (2023, [Tesis de doctorado])

Las enfermedades parasitarias son un problema de salud pública que afectan a más de la

quinta parte de la población a nivel mundial. Además de la morbilidad que generan, sino

son tratadas y controladas de manera adecuada pueden llegar a causar la muerte.

En el mercado existen diferentes antiparasitarios comerciales, que si bien son efectivos,

presentan diferentes efectos adversos tanto para el individuo parasitado (i.e. destrucción

de la microbiota intestinal) como para el medio ambiente. Este panorama señala la

relevancia de desarrollar tratamientos antiparasitarios más amigables con el ambiente y con

menores efectos adversos que estén disponibles actualmente en el mercado. Productos

obtenidos a partir de plantas con propiedades anti-parasitarias, cultivadas in vitro en

condiciones controladas, podrían representar una alternativa realista. Entre ellas figura la

planta Carica papaya, especie de zonas tropicales y subtropicales del planeta a cuyos frutos

se les adjudica actividades antiparasitarias. Estas propiedades se atribuyen a algunos de

sus compuestos concentrados en el latex y en las semillas como la papaina, la

quimiopapaína, la lisozima, la glicil-endopeptidasa, la proteasa de cisteína y el benzil-

isotiocinato.

El objetivo del presente trabajo fue evaluar la actividad antiparasitaria in vitro e in vivo de

un conjunto de callos y líneas de células de papaya de Carica papaya contra cisticercos de

Taenia crassiceps (cestodo) y contra trofozoitos de Entamoeba histolytica (protozoario). Los

extractos acuosos obtenidos a partir de callos y células cultivados en placa o en suspensión,

respectivamente, de las diferentes líneas de papaya revelaron alta capacidad cisticida

(>98% de mortalidad) in vitro contra cisticercos de Taenia crassiceps. En la evaluación in

vivo la línea no transformada obtuvo mayor efecto cisticida a 10mg/mL reduciendo el

número de cisticercos gemantes y aumentando los cisticercos calcificados en niveles

similares a los obtenidos utilizando antiparasitarios comerciales (albendazol y niclosamida).

Las líneas transformadas y sin transformar de papaya evaluadas indujeron una alta

capacidad amebicida (97% de mortalidad) in vitro contra trofozoitos de Entamoeba

histolytica. Las diferentes líneas transformadas y sin transformar de papaya redujeron

significativamente el número de abscesos amebianos y previnieron la hepatomegalia de

manera no significativamente diferente que el anti-parasitario comercial (metronidazol).

Los resultados generados en el presente estudio señalan al extracto acuoso obtenido a

partir de cultivos en suspensión de células de papaya transformada y no transformada

indujeron alto nivel de protección in vitro e in vivo por lo tanto; este es un producto efectivo

para el tratamiento de la cisticercosis y la amebiasis.

Parasitic diseases are a public health problem that affect more than a fifth of the population

worldwide. Additionally, and along with the morbidity the produce, they can cause death if

they are not treated and controlled adequately.

There are different commercial antiparasitic on the market which, although effective,

present different adverse effects both for the individual (i.e., destruction of the intestinal

microbiota) and for the environment alike. This panorama points out the relevance of

developing more environmentally friendly antiparasitic treatments with fewer adverse effects

than the ones currently available on the market. Products obtained from plants with anti-

parasitic properties, grown in vitro under controlled conditions, could represent a realistic

alternative. Among them is the Carica papaya, a species from tropical and subtropical areas

of the planet whose fruits are believed to have antiparasitic activities. These properties are attributed to some of its compounds concentrated in the latex and seeds such as papain,

chymopapain, lysozyme, glycyl-endopeptidase, cysteine-proteinase and benzyl-

isothiocyanate.

The objective of the present work is to evaluate the in vitro and in vivo antiparasitic activity

of a set of papaya callus and cell lines from Carica papaya against cysticerci of Taenia

crassiceps (cestode) and against trophozoites of Entamoeba histolytica (protozoan). The

aqueous extracts obtained from callus and cells cultured in plates or in suspension,

respectively, of the different papaya lines revealed high cysticidal capacity (>98% mortality)

in vitro against Taenia crassiceps cysticerci. Meanwhile, in the in vivo evaluation, the non-

transformed line obtained a greater cysticidal effect at 10 mg/mL, reducing the number of

budding cysticerci and increasing calcified cysticerci at levels like those obtained using

commercial antiparasitic (albendazole and niclosamide). The papaya lines evaluated

induced a high amoebicidal capacity (97% mortality) in vitro against Entamoeba histolytica

trophozoites. The different papaya lines significantly reduced the number of amoebic

abscesses and prevented hepatomegaly in a non-significantly different manner than the

commercial anti-parasitic (metronidazole).

The results produced in this thesis indicate that the aqueous extract obtained from

suspension cultures of transformed and non-transformed papaya cells induced a high level

of protection in vitro and in vivo. Therefore, this may represent an effective product for the

treatment of cysticercosis and amoebiasis.

CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS Carica papaya, antiparasitario, células en suspensión, T. crassiceps, E. histolytica. Carica papaya, antiparasitic, in-suspension cells, T. crassiceps, E. histolytica.

Voter´´´'s dilemma between honest and competent candidates in the 2018 elections in Mexico and Brazil

José Daniel Sousa Oliva (2023, [Artículo, Artículo])

This article is dedicated to understanding and explaining the electoral dilemma “Dishonest, but competent” and “Honest, but incompetent” in the elections of legislators, governors and municipal presidents in 2018 in Mexico and Brazil. The research questions that guided the investigation are: Why are there voters in Mexico and Brazil who vote for “dishonest” candidates? And how do the voters of those countries decide their vote in the face of this dilemma? The theoretical approach of this work is Social Psychology through two analytical tools: the Funnel of Causality and the Tripartite Model of Attitudes. The methodology is mixed, quantitative and qualitative, using statistical models with data from the international surveys World Values Survey and Comparative Studies of Electoral Systems, as well as the application of Focus Groups in the distance modality. In this way, four categories of voter are proposed: moralist, moralist-moderate, pragmatic-moderate and pragmatic. The arguments of this work are: first, that regardless of cultural differences, there is an “affective voter” “non-rational” who makes decisions based on emotions and intuition, demonstrating that the affective components of attitudes are more relevant than the cognitive ones in electoral choice; second, that voting for “dishonest” candidates is determined under a greater influence of “short-term factors” such as candidate characteristics and short-term events rather than “long-term factors” such as party loyalties and ideology.

politics, electoral behavior, political culture, democracy, public opinion. política, comportamiento electoral, cultura política, democracia, opinión pública. CIENCIAS SOCIALES CIENCIAS SOCIALES

Voter´´´'s dilemma between honest and competent candidates in the 2018 elections in Mexico and Brazil

José Daniel Sousa Oliva (2023, [Artículo, Artículo])

This article is dedicated to understanding and explaining the electoral dilemma “Dishonest, but competent” and “Honest, but incompetent” in the elections of legislators, governors and municipal presidents in 2018 in Mexico and Brazil. The research questions that guided the investigation are: Why are there voters in Mexico and Brazil who vote for “dishonest” candidates? And how do the voters of those countries decide their vote in the face of this dilemma? The theoretical approach of this work is Social Psychology through two analytical tools: the Funnel of Causality and the Tripartite Model of Attitudes. The methodology is mixed, quantitative and qualitative, using statistical models with data from the international surveys World Values Survey and Comparative Studies of Electoral Systems, as well as the application of Focus Groups in the distance modality. In this way, four categories of voter are proposed: moralist, moralist-moderate, pragmatic-moderate and pragmatic. The arguments of this work are: first, that regardless of cultural differences, there is an “affective voter” “non-rational” who makes decisions based on emotions and intuition, demonstrating that the affective components of attitudes are more relevant than the cognitive ones in electoral choice; second, that voting for “dishonest” candidates is determined under a greater influence of “short-term factors” such as candidate characteristics and short-term events rather than “long-term factors” such as party loyalties and ideology.

politics, electoral behavior, political culture, democracy, public opinion. política, comportamiento electoral, cultura política, democracia, opinión pública. CIENCIAS SOCIALES CIENCIAS SOCIALES

Diseño y activismo artístico

Olivia Fragoso-Susunaga (2023, [Capítulo de libro])

En el 2015, las Naciones Unidas proponen una serie de objetivos dirigidos a convocar a los habitantes del mundo a realizar acciones orientadas a acabar con la pobreza, mejorar las condiciones del planeta y lograr que, para el 2030, todas las personas puedan gozar de paz y bienestar. A estos objetivos se les conoce como los Objetivos de Desarrollo Sostenible (ODS). La educación superior juega un papel fundamental en el logro de los ODS. La UAM y, en el caso que nos compete, el CyAD están llamados a colaborar en esta tarea que nos involucra a todos y todas quienes formamos la comunidad universitaria. Este trabajo es una reflexión sobre la importancia que tiene la formación en activismo artístico en la educación del diseño para el logro de los ODS. Se propone que enfatizar el vínculo entre el diseño y el activismo artístico es parte de un escenario futuro indiscutiblemente necesario en el currículo de licenciatura en el CyAD.

In 2015, the United Nations proposed a series of goals aimed at calling on the world’s inhabitants to take action to end poverty, improve the conditions of the planet and ensure that by 2030 all people can enjoy peace and well-being. These goals are known as the Sustainable Development Goals (SDGs). Higher education plays a fundamental role in the achievement of the SDGs, the UAM and, in the case that concerns us, the CyAD are called to collaborate in this task that involves all of us who form the university community. This work is a reflection on the importance of training in artistic activism in design education for the achievement of the SDGs. It is proposed that emphasizing the link between design and art activism is part of an indisputably necessary future scenario in the undergraduate curriculum at CyAD.

Activismo artístico, educación del diseño, cultura. Artistic activism, design education, culture. Sustainable Development Goals. Art and social action. Education, Higher--Social aspects. Educational change. Artists--Political activity. Universidad Autónoma Metropolitana. Unidad Azcapotzalco. División de Ciencias y Artes para el Diseño. Desarrollo sustentable. Participación social. Cambio educativo. NX180.P64 HUMANIDADES Y CIENCIAS DE LA CONDUCTA CIENCIAS DE LAS ARTES Y LAS LETRAS

Phylogenetic relationships of Pseudo-nitzschia subpacifica (Bacillariophyceae) from the Mexican Pacific, and its production of domoic acid in culture

Sonia Quijano (2020, [Artículo])

Pseudo-nitzschia is a cosmopolitan genus, some species of which can produce domoic acid (DA), a neurotoxin responsible for the Amnesic Shellfish Poisoning (ASP). In this study, we identified P. subpacifica for the first time in Todos Santos Bay and Manzanillo Bay, in the Mexican Pacific using SEM and molecular methods. Isolates from Todos Santos Bay were cultivated under conditions of phosphate sufficiency and deficiency at 16°C and 22°C to evaluate the production of DA. This toxin was detected in the particulate (DAp) and dissolved (DAd) fractions of the cultures during the exponential and stationary phases of growth of the cultures. The highest DA concentration was detected during the exponential phase grown in cells maintained in P-deficient medium at 16°C (1.14 ± 0.08 ng mL-1 DAd and 4.71 ± 1.11 × 10−5 ng cell-1 of DAp). In P-sufficient cultures DA was higher in cells maintained at 16°C (0.25 ± 0.05 ng mL-1 DAd and 9.41 ± 1.23 × 10−7 ng cell-1 of DAp) than in cells cultured at 22°C. Therefore, we confirm that P. subpacifica can produce DA, especially under P-limited conditions that could be associated with extraordinary oceanographic events such as the 2013–2016 "Blob" in the northeastern Pacific Ocean. This event altered local oceanographic conditions and possibly generated the presence of potential harmful species in areas with economic importance on the Mexican Pacific coast. © 2020 Quijano-Scheggia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

domoic acid, domoic acid, kainic acid, Article, cell growth, controlled study, diatom, Mexico, morphology, nonhuman, Pacific Ocean, phylogeny, plant cell, plant growth, Pseudo nitzschia, toxin analysis, cell culture technique, classification, diatom, CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA CIENCIAS DE LA TIERRA Y DEL ESPACIO OCEANOGRAFÍA OCEANOGRAFÍA